COL8A1

Overview

COL8A1 encodes the alpha1 chain of type VIII collagen, a short-chain collagen found in basement membranes and desmoplastic stroma. Its expression correlates with CAF activation in several solid tumors.

Alterations observed in the corpus

• Expression positively correlated with stromal SEMA7A in GBC tissues, part of the fibrillar collagen signature associated with desmoplastic stroma and CAF activation PMID:24997986

Cancer types (linked)

• GBC: COL8A1 co-expressed with SEMA7A in the desmoplastic stroma of gallbladder cancer PMID:24997986

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24997986

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