CP
Overview
CP (Ceruloplasmin) is a copper-binding glycoprotein with ferroxidase activity involved in iron metabolism. It was identified as a significantly mutated gene in African American colorectal cancers, suggesting an ethnicity-associated role in CRC.
Alterations observed in the corpus
- Identified as a significantly mutated gene in African American colorectal cancers in both discovery and validation cohorts (103 AA vs. 129 Caucasian CRC samples); part of the 20-gene panel preferentially mutated in AA CRCs PMID:25583493
Cancer types (linked)
- Colorectal cancer: identified in a significantly mutated gene panel enriched in African American CRC patients PMID:25583493
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Functional significance of CP mutations in AA CRC has not been experimentally validated PMID:25583493
Sources
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