CPQ
Overview
CPQ (carboxypeptidase Q) is a metalloprotease enzyme. It has been newly nominated as a significantly mutated gene in papillary renal cell carcinoma through comprehensive genomic analysis of non-clear-cell RCC.
Alterations observed in the corpus
- Newly nominated significantly mutated gene in pRCC by multi-method driver analysis; oncogenic vs passenger status unestablished PMID:25401301
Cancer types (linked)
- PRCC: CPQ identified among new significantly mutated genes in papillary renal cell carcinoma PMID:25401301
Co-occurrence and mutual exclusivity
- Nominated alongside NF2, SLC5A3, PNKD, LRP2, CHD3, NHERF1, SETD2, and CRTC1 as new significantly mutated genes in pRCC PMID:25401301
Therapeutic relevance
- No therapeutic relevance established; functional role in pRCC tumorigenesis is unknown PMID:25401301
Open questions
- Functional characterization of CPQ mutations in cancer is lacking; the authors flag CPQ alongside other newly nominated genes as requiring validation PMID:25401301
Sources
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