CRACDL

Overview

CRACDL (also referred to in the literature by its previous designation KIAA1211) is a gene of currently unclear biological function. It emerged as a significantly mutated gene in small cell lung cancer (SCLC) whole-genome sequencing, but its role in cancer pathogenesis has not been functionally characterized.

Alterations observed in the corpus

• Significantly mutated gene in SCLC (110-tumour WGS cohort); biological function described as “much less clear” by authors; functional experiments required to establish role PMID:26168399

Cancer types (linked)

• SCLC: Identified as significantly mutated in a 110-tumour whole-genome sequencing cohort PMID:26168399

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional role in SCLC and cancer biology is unknown; authors explicitly note that experiments will be required to clarify its significance PMID:26168399

Sources

• PMID:26168399

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