CRTC1

Overview

CRTC1 (CREB-regulated transcriptional coactivator 1) is a coactivator of the CREB transcription factor. In oncology, CRTC1 is best known as a fusion partner in mucoepidermoid carcinoma (CRTC1-MAML2 fusion). In the sarcoma corpus, CRTC1 appears as a rare shared somatic SNV across intratumoral subclones.

Alterations observed in the corpus

  • CRTC1 was one of three shared SNVs (alongside ARID2 and MAP3K1) detected across all four synchronous metastatic lesions of SARC0075 (epithelioid sarcoma with undifferentiated pleomorphic features) in a UCLA sarcoma patient-derived tumor organoid (PDTO) study; the CNV landscape across the four lesions was substantially divergent, including whole-genome duplications and arm-level events, despite this shared SNV clonal ancestor PMID:39305899.
  • Newly nominated significantly mutated gene in papillary renal cell carcinoma (pRCC) by multi-method driver analysis PMID:25401301

Cancer types (linked)

  • EPIS / undifferentiated pleomorphic sarcoma — CRTC1 shared SNV across four metastatic lesions, demonstrating clonal ancestry with divergent copy-number evolution PMID:39305899.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Not directly therapeutically targeted in the corpus; shared SNV status in heterogeneous metastatic sarcoma illustrates limits of single-biopsy PDTO drug screening PMID:39305899.

Open questions

  • Functional significance of CRTC1 point mutations in sarcoma (vs the canonical CRTC1-MAML2 fusion of mucoepidermoid carcinoma) is not established in this corpus.

Sources

This page was processed by entity-page-writer on 2026-05-01. - PMID:25401301

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