CSF1R

Overview

CSF1R is a receptor tyrosine kinase that governs macrophage lineage survival and is recurrently altered in histiocytic neoplasms.

Alterations observed in the corpus

• CSF1R mutated in 2.4% of histiocytosis patients profiled via MSK-IMPACT through the Make-an-IMPACT direct-to-patient program PMID:36862133.

Cancer types (linked)

• Histiocytosis (LCH/ECD) — CSF1R is among the potentially actionable kinase drivers catalogued alongside BRAF, MAP2K1, KRAS, ALK, and NTRK1 PMID:36862133.

Co-occurrence and mutual exclusivity

• CSF1R is part of the mutually informative kinase-driver set observed across histiocytosis cases PMID:36862133.

Therapeutic relevance

• CSF1R is a target for kinase inhibitors; histiocytosis patients with matched targeted therapy in this program had a 17/18 (94%) clinical benefit rate overall PMID:36862133.

Open questions

• Specific CSF1R-inhibitor response in histiocytosis is not separately reported in this cohort PMID:36862133.

Sources

• PMID:36862133

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