CTCF
Overview
CTCF (CCCTC-Binding Factor) encodes an 11-zinc-finger transcriptional regulator with roles in chromatin organization, gene insulation, and genome architecture. Loss-of-function mutations in CTCF are recurrent in several cancer types and may dysregulate gene expression through altered topologically associating domain (TAD) boundaries.
Alterations observed in the corpus
- Recurrently altered across endometrial carcinoma subtypes (referenced in mutation panels across multiple subgroups) PMID:23636398
- Mechanistically implicated in Ewing sarcoma: STAG2 interacts with CTCF to regulate chromatin insulation at loci including CDKN2A; CTCF itself carries somatic mutations in 3/112 cases PMID:25223734
- CTCF was a recurrently mutated transcriptional regulator in colorectal cancer; CTCF/cohesin-binding sites are known hotspots for somatic mutations in MSS CRC (Katainen et al. 2015), and CTCF was among the newly significant CRC drivers identified in this 619-tumor neoantigen study PMID:27149842.
- CTCF was identified as a chromatin-function Mut-driver in breast cancer; 22.6% of all breast tumors harbored a coding mutation in one of seven chromatin-function Mut-drivers including CTCF PMID:27161491.
Cancer types (linked)
- Endometrial carcinoma: recurrent alterations across multiple molecular subtypes PMID:23636398
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual-exclusivity data in the corpus.
Therapeutic relevance
- No direct therapeutic data in the corpus.
Open questions
- Functional consequences of CTCF alterations in specific endometrial carcinoma subtypes.
Sources
This page was processed by entity-page-writer on 2026-05-09. - PMID:25223734
This page was processed by wiki-cli on 2026-05-12. - PMID:27149842
This page was processed by wiki-cli on 2026-05-14. - PMID:27161491
This page was processed by wiki-cli on 2026-05-14.