CTNNA1
Overview
CTNNA1 encodes alpha-E-catenin, a cytoskeletal linker protein that connects cadherin–catenin complexes to the actin cytoskeleton. Germline loss-of-function variants are the second-most-common cause of Hereditary Diffuse Gastric Cancer (HDGC) after CDH1. Somatic variants are also recurrent in familial intestinal gastric cancer (FIGC).
Alterations observed in the corpus
- Second-most-common HDGC gene (germline); also a recurrent somatic variant in FIGC tumors; included in the recommended multigene panel for hereditary/familial gastric cancer PMID:24816255
- CTNNA1 was nominated as a breast cancer Mut-driver TSG via combined homozygous-deletion plus inactivating-mutation evidence; part of the ‘tissue-organisation’ cluster with CDH1 and AFDN/MLLT4; functional confirmation of CTNNA1 as a breast-cancer TSG was flagged as future work PMID:27161491.
Cancer types (linked)
- STAD: Germline CTNNA1 loss-of-function causes HDGC; somatic variants recur in FIGC; standard GC multigene panel includes CTNNA1 PMID:24816255
Co-occurrence and mutual exclusivity
No data in current corpus.
Therapeutic relevance
Not a direct therapeutic target in current corpus.
Open questions
No conflicts in current corpus.
Sources
This page was processed by entity-page-writer on 2026-05-11. - PMID:27161491
This page was processed by wiki-cli on 2026-05-14.