CTNND1
Overview
CTNND1 encodes p120-catenin (delta-1-catenin), a member of the Armadillo repeat protein family that stabilizes cadherin complexes at adherens junctions and regulates cell–cell adhesion and motility. Germline variants have been proposed as a predisposition gene for early-onset gastric cancer in familial non-hereditary gastric cancer (FNHGC) contexts.
Alterations observed in the corpus
- Newly proposed germline predisposition gene for early-onset gastric cancer (Herrera-Pariente et al. 2024); disrupts cell–cell interactions, potentiates motility and metastasis; candidate explanation for a subset of FNHGC PMID:24816255
Cancer types (linked)
- STAD: Germline CTNND1 variants proposed as FNHGC predisposition; disrupts adhesion and promotes invasiveness PMID:24816255
Co-occurrence and mutual exclusivity
No data in current corpus.
Therapeutic relevance
Not a direct therapeutic target in current corpus.
Open questions
No conflicts in current corpus.
Sources
This page was processed by entity-page-writer on 2026-05-11.