CXCL16

Overview

CXCL16 (C-X-C Motif Chemokine Ligand 16) is a hepatic sinusoidal endothelial cell chemokine that recruits CXCR6-expressing NKT cells. In the context of cholangiocarcinoma and bile acid biology, secondary bile acid DCA reduces CXCL16 expression, impairing NKT-cell-mediated immune surveillance.

Alterations observed in the corpus

• Hepatic sinusoidal endothelial-cell chemokine reduced by secondary bile acid DCA, impairing CXCR6+ NKT-cell recruitment in cholangiocarcinoma/liver cancer microenvironment PMID:25608663

Cancer types (linked)

• Cholangiocarcinoma: CXCL16 downregulation impairs NKT-cell recruitment to the tumor microenvironment PMID:25608663

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25608663

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