CYLD

Overview

CYLD (CYLD Lysine 63 Deubiquitinase) is a tumor suppressor gene encoding a deubiquitinase that negatively regulates NF-kB signaling. Germline loss-of-function mutations cause cylindromatosis; somatic truncating mutations have been observed across multiple cancer types including adenoid cystic carcinoma.

Alterations observed in the corpus

• Truncating mutation in ACC exome-sequencing cohort (n=24); classified as known cancer/tumor-suppressor gene PMID:23778141
• NF-kB pathway regulator recurrently mutated in multiple myeloma (MM): 5 patients with point mutations plus inclusion in a significant homozygous-deletion peak by GISTIC (n=153 patients); one of the 11 significantly mutated genes (q<0.1) in MM PMID:24434212
• Recurrent mutations in ~19% of thymic carcinomas PMID:24974848
• Mentioned in study PMID:26855148

Cancer types (linked)

• Adenoid cystic carcinoma (ACC): truncating mutation observed PMID:23778141

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:23778141

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This page was processed by wiki-cli on 2026-05-09. - PMID:24974848

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