DCLK1
Overview
DCLK1 (Doublecortin-like kinase 1) encodes a serine/threonine kinase with roles in neuronal migration and stem cell maintenance. It has been flagged as a candidate driver in cutaneous squamous cell carcinoma (cSCC) via MutSig analysis, though low allelic fractions raise uncertainty about its driver versus passenger status.
Alterations observed in the corpus
- Identified as a MutSig hit (q<0.1) in whole-exome sequencing of 39 aggressive cSCC tumors; however, low allelic fractions suggest it may be a passenger rather than a true driver PMID:25303977.
Cancer types (linked)
- CSCC: flagged by MutSig in aggressive, UV-driven cutaneous SCC; driver status uncertain due to low allelic fractions PMID:25303977.
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data reported in the corpus.
Therapeutic relevance
- No direct therapeutic associations reported in the corpus.
Open questions
- Whether DCLK1 is a true driver or passenger in cSCC requires further functional validation given the low allelic fractions observed PMID:25303977.
Sources
This page was processed by entity-page-writer on 2026-05-11.