DDR2

Overview

DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2) is a receptor tyrosine kinase activated by fibrillar collagens. It plays roles in cell migration, invasion, and proliferation. DDR2 mutations have been identified in lung squamous cell carcinoma and nominated as a therapeutic target in that disease.

Alterations observed in the corpus

  • Mutation identified in lung squamous cell carcinoma (178 tumors, TCGA); previously nominated as a therapeutic target PMID:22960745
  • Candidate RTK alteration across HPV groups in HNSCC (Fig. 3); part of the comprehensive set of RTK alterations identified in the TCGA HNSCC study PMID:25631445
  • TRABD-DDR2 fusion identified in an HNSC sample; the promoter-swap drives DDR2 overexpression and was proposed as a candidate for dasatinib therapy; DDR2 fusions were also seen in nine additional samples across five cancer types in the TCGA pan-cancer fusion landscape analysis PMID:29617662.

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Nominated as a candidate therapeutic target in lung squamous cell carcinoma based on somatic mutation data PMID:22960745

Open questions

  • Functional validation of DDR2 mutations as drivers in LUSC not performed in the TCGA study PMID:22960745

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:25631445

This page was processed by crosslinker on 2026-05-14. - PMID:29617662

This page was processed by wiki-cli on 2026-05-15.