DDX1
Overview
DDX1 (DEAD-box helicase 1) is an RNA helicase involved in RNA metabolism, including splicing, translation, and stress granule formation. In cancer genomics, DDX1 has been identified as highly expressed in cholangiocarcinoma (CCA) with potential prognostic significance and roles in shaping the tumor immune microenvironment, though functional validation remains pending.
Alterations observed in the corpus
- Highly expressed in CCA with prognostic and immune-microenvironment implications; functional validation of its oncogenic role is pending. PMID:25526346
Cancer types (linked)
- CCA (Cholangiocarcinoma): High expression reported with prognostic significance; immune microenvironment implications described in a comprehensive CCA genomic review. PMID:25526346
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data available in the current corpus.
Therapeutic relevance
- No direct therapeutic targeting described in the current corpus. Prognostic and immune-microenvironment context may inform patient stratification in CCA.
Open questions
- Functional validation of DDX1’s oncogenic role in CCA is explicitly noted as pending. PMID:25526346
Sources
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