DEPDC5
Overview
DEPDC5 (DEP domain-containing protein 5) encodes a subunit of the GATOR1 complex, a negative regulator of mTORC1 signaling. In the context of HCC susceptibility, a GWAS susceptibility locus/SNP at or near DEPDC5 has been associated with HBV- or HCV-related HCC risk.
Alterations observed in the corpus
- GWAS susceptibility locus/SNP associated with HBV- or HCV-related HCC risk; identified as one of several germline susceptibility loci in a 2014 comprehensive HCC genomics review PMID:24735922
Cancer types (linked)
- HCC: germline susceptibility SNP associated with viral hepatitis-related HCC PMID:24735922
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data available in this corpus.
Therapeutic relevance
- No direct therapeutic relevance reported in this corpus.
Open questions
- SNP-association studies in HCC suffer from poor control selection, retrospective single-center designs, underpowering, and lack of cross-ancestry validation; the DEPDC5 association requires independent replication PMID:24735922.
Sources
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