DKK2

Overview

DKK2 (Dickkopf WNT signaling pathway inhibitor 2) is a secreted WNT pathway antagonist. It has been identified as a transcriptional target of the EWS::FLI1 fusion oncogene in Ewing sarcoma.

Alterations observed in the corpus

  • Established EWS::FLI1 transcriptional target; induced upon oncogene expression in heMSCs and validated by RT-qPCR in Ewing sarcoma cell-of-origin model PMID:25186949

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

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