DLC1
Overview
DLC1 (deleted in liver cancer 1) encodes a RhoGAP-domain tumor suppressor that is frequently deleted in hepatocellular carcinoma. Its chromosomal locus is a GWAS susceptibility locus with SNPs associated with HBV- or HCV-related HCC risk, in addition to its role as a somatic tumor suppressor.
Alterations observed in the corpus
- GWAS susceptibility locus/SNP associated with HBV- or HCV-related HCC risk; identified as one of several germline susceptibility loci in a 2014 comprehensive HCC genomics review PMID:24735922
Cancer types (linked)
- HCC: germline susceptibility SNP associated with viral hepatitis-related HCC; historically characterized as a somatic deletion-based tumor suppressor in HCC PMID:24735922
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data available in this corpus.
Therapeutic relevance
- No direct therapeutic relevance reported in this corpus.
Open questions
- SNP-association studies in HCC suffer from poor control selection, retrospective single-center designs, underpowering, and lack of cross-ancestry validation; the DLC1 association requires independent replication PMID:24735922.
Sources
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