DNM2
Overview
DNM2 (Dynamin 2) encodes a large GTPase involved in membrane tubulation and vesicle formation. In cancer genomics, DNM2 has been identified as a putative fusion partner in structural rearrangements, and its disruption may affect vesicle trafficking and cytokinesis pathways.
Alterations observed in the corpus
- Putative fusion partner with SMARCA4 (SMARCA4–DNM2 fusion) detected by whole-genome sequencing in esophageal adenocarcinoma PMID:23525077
Cancer types (linked)
- Esophageal adenocarcinoma: detected as a structural fusion partner by WGS PMID:23525077
Co-occurrence and mutual exclusivity
- SMARCA4–DNM2 fusion observed in the context of SWI/SNF chromatin-remodeling gene disruption in EAC PMID:23525077
Therapeutic relevance
- No direct therapeutic data in the corpus.
Open questions
- Functional significance and frequency of the SMARCA4–DNM2 fusion in EAC remain to be determined.
Sources
This page was processed by crosslinker on 2026-05-09.