DYRK1A

Overview

DYRK1A (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A) is a serine/threonine/tyrosine kinase involved in cell-cycle regulation, DNA damage response, and transcriptional control. It has been identified as a novel driver gene in chronic lymphocytic leukemia (CLL), where it is implicated in the DNA damage response pathway.

Alterations observed in the corpus

• Identified as a DNA damage response driver in CLL; enriched in a comprehensive WES study of 538 CLL patients PMID:26466571

Cancer types (linked)

• CLL — novel driver candidate in chronic lymphocytic leukemia, classified in the DNA damage response pathway PMID:26466571

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional validation of DYRK1A as a CLL driver beyond statistical discovery (MutSig2CV) is pending PMID:26466571

Sources

• PMID:26466571

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