E2F1

Overview

E2F1 encodes a transcription factor that is a key regulator of cell-cycle entry and DNA synthesis. As a downstream effector of the Rb pathway, E2F1 activity is often unleashed by CDKN2A/RB1 loss or cyclin D/E amplification. In bladder TCC, E2F1 has been identified as a focal amplification target.

Alterations observed in the corpus

  • Focal amplification in bladder TCC PMID:24121792
  • Focal amplification predominantly in HPV(+) HNSCC; also shows increased expression via let-7c-5p/miR-100-5p loss PMID:25631445
  • High E2F1 expression correlates with CCP score (r = 0.8, P < 0.001) and FA pathway activity (r = 0.78, P < 0.001) in mCRPC; RB1 loss is associated with elevated E2F1 and a 15-gene FA signature; E2F1 is inversely correlated with AR transcriptional activity (P < 0.001) PMID:26928463

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct drug data reported in the current corpus; E2F pathway dysregulation is broadly linked to CDK inhibitor sensitivity.

Open questions

  • Relative contribution of E2F1 vs E2F3 amplification to bladder cancer pathogenesis is not resolved in the current corpus.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:25631445

This page was processed by crosslinker on 2026-05-14. - PMID:26928463

This page was processed by wiki-cli on 2026-05-14.