EGR1
Overview
EGR1 (Early Growth Response 1) is a zinc-finger transcription factor that regulates cell proliferation, differentiation, and apoptosis. In cancer genomics, EGR1 mutations have been observed in multiple myeloma bearing signatures of AID/somatic-hypermutation activity.
Alterations observed in the corpus
- EGR1 harbors 7 mutations clustered 5’ and enriched in WRCY motifs (q < 0.1) in multiple myeloma, consistent with an AID/somatic-hypermutation pattern; borderline statistical significance in MM genomic characterization PMID:24434212
Cancer types (linked)
- MM: borderline-significant somatic-hypermutation-patterned mutations clustered in WRCY motifs PMID:24434212
Co-occurrence and mutual exclusivity
- EGR1 mutations show WRCY-motif clustering suggesting AID activity as a shared mutational process with other MM driver genes PMID:24434212
Therapeutic relevance
- No direct therapeutic targeting reported in corpus.
Open questions
- Whether EGR1 mutations are true drivers or AID-induced passengers in multiple myeloma remains unresolved given borderline significance PMID:24434212
Sources
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