EIF2D
Overview
EIF2D (Eukaryotic Translation Initiation Factor 2D) encodes a non-canonical translation initiation factor. It was identified as a candidate driver gene in aggressive cutaneous squamous cell carcinoma (cSCC) through inactivation-bias algorithms, though its functional role in cancer remains poorly characterized.
Alterations observed in the corpus
- Significant by three alternative driver-detection methods (inactivation-bias chi-square and multinomial algorithms, plus IntOGen) but not by MutSig in 39 aggressive cSCC tumors; classified as a candidate driver PMID:25303977.
Cancer types (linked)
- CSCC: candidate driver identified by inactivation-bias analysis in whole-exome sequencing of aggressive UV-driven cSCC PMID:25303977.
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data reported in the corpus.
Therapeutic relevance
- No direct therapeutic associations reported in the corpus.
Open questions
- Functional role of EIF2D in cSCC tumorigenesis is uncharacterized; driver versus passenger status requires experimental validation PMID:25303977.
Sources
This page was processed by entity-page-writer on 2026-05-11.