ELF4

Overview

ELF4 (E74 Like ETS Transcription Factor 4) is an ETS family transcription factor involved in immune cell development and DNA damage response signaling. It has been identified as a novel driver gene in chronic lymphocytic leukemia (CLL), where it is classified among DNA damage response pathway drivers.

Alterations observed in the corpus

• Identified as a DNA damage response driver in CLL; enriched in a comprehensive WES study of 538 CLL patients PMID:26466571

Cancer types (linked)

• CLL — novel driver candidate in chronic lymphocytic leukemia, classified in the DNA damage response pathway PMID:26466571

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional validation of ELF4 as a CLL driver beyond statistical discovery (MutSig2CV) is pending PMID:26466571

Sources

• PMID:26466571

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