EML6

Overview

EML6 (Echinoderm Microtubule Associated Protein Like 6) is a member of the EML family of microtubule-associated proteins. It was identified as a significantly mutated gene in African American colorectal cancers, suggesting a role in ethnicity-associated mutational landscapes in CRC.

Alterations observed in the corpus

• Identified as a significantly mutated gene in African American (AA) CRCs (significantly mutated in both discovery and validation cohorts); included in the 20-gene AA-enriched panel PMID:25583493

Cancer types (linked)

• Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

• Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

• PMID:25583493

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