EOMES

Overview

EOMES (Eomesodermin) encodes a T-box transcription factor involved in brain development and neuronal differentiation. In medulloblastoma, EOMES shows methylation-dependent differential expression across molecular subgroups and is inversely co-expressed with TBR1 in Group 4 tumors, implicating it in subgroup-specific developmental programs.

Alterations observed in the corpus

• Inversely expressed with TBR1 in Group 4 medulloblastoma; methylation-dependent differential expression across subgroups identified by WGS/WES (ICGC, 76 tumors) PMID:22832583

Cancer types (linked)

• MB (medulloblastoma): Subgroup-specific expression pattern — inversely correlated with TBR1 in Group 4; epigenetic (methylation) regulation implicated PMID:22832583

Co-occurrence and mutual exclusivity

• Inversely expressed with TBR1 in Group 4 medulloblastoma; both are T-box transcription factors with complementary subgroup expression patterns PMID:22832583

Therapeutic relevance

• No direct therapeutic targeting reported in the corpus; subgroup-specific epigenetic regulation suggests potential relevance for epigenetic therapy strategies in Group 4 medulloblastoma.

Open questions

• Whether EOMES expression differences are driver or passenger events in Group 4 medulloblastoma remains unresolved.
• Functional consequences of methylation-mediated silencing/activation of EOMES across subgroups not yet characterized.

Sources

• PMID:22832583

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