EP400

Overview

EP400 (E1A Binding Protein P400) encodes a component of the NuA4 histone acetyltransferase and chromatin-remodeling complex. It is among the large set of chromatin-remodeling genes found to be recurrently mutated in bladder transitional cell carcinoma (TCC), contributing to the broadly disrupted epigenetic landscape characteristic of that cancer type.

Alterations observed in the corpus

Mutation in bladder TCC as part of a chromatin-remodeling gene cluster altered in 58% of cases PMID:24121792

Cancer types (linked)

BLCA: somatic mutation; part of the 58% chromatin-remodeling gene alteration burden in TCC PMID:24121792

Co-occurrence and mutual exclusivity

Co-occurs with mutations in KDM6A, ARID1A, KMT2A/C/E, EP300, CREBBP, NCOR1, CHD6, SMARCA4, KDM5A/B as part of the chromatin-remodeling alteration set in TCC PMID:24121792

Therapeutic relevance

No direct drug targets reported in the current corpus; chromatin remodeling pathway disruption in TCC is a candidate for epigenetic therapy investigation.

Open questions

Precise mutation frequency and functional role of EP400 in TCC pathogenesis are not yet characterized.

Sources

PMID:24121792

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