EPHA2

Overview

EPHA2 (Ephrin Type-A Receptor 2) is a receptor tyrosine kinase of the EPH family. EPH receptors are the largest family of receptor tyrosine kinases and play roles in cell migration, invasion, and tumor angiogenesis. EPHA2 has been identified as a candidate RTK alteration in head and neck squamous cell carcinoma.

Alterations observed in the corpus

• Candidate RTK alteration across HPV groups in HNSCC (Fig. 3) PMID:25631445

Cancer types (linked)

• Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

• Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

• PMID:25631445

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