EPHA7

Overview

One-paragraph summary of the gene’s role and why it matters in cancer genomics.

Alterations observed in the corpus

• Mutation classes (missense / truncating / fusion / amplification / deletion) with links to the papers that report them.
• Identified among significantly mutated ephrin receptor kinases in 188 primary LUAD tumours (TSP cohort); part of the receptor tyrosine kinase alteration landscape. PMID:18948947
• Mutations identified in SCLC (29 tumors, CLCGP WES/WGS); candidate tumor suppressor, previously described in lymphoma PMID:22941188
• WNT-subgroup-associated mutation in medulloblastoma, observed in 8% of WNT MBs in the ICGC/CBTTC cohort (n=491) PMID:28726821.

Cancer types (linked)

• Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

• Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

This page was processed by crosslinker on 2026-05-05. - PMID:18948947

This page was processed by crosslinker on 2026-05-05. - PMID:22941188

This page was processed by wiki-cli on 2026-05-06. - PMID:28726821

This page was processed by wiki-cli on 2026-05-15.