ETV4

Overview

ETV4 (ETS Variant Transcription Factor 4) is an ETS-family transcription factor that can be overexpressed via gene fusion with androgen-responsive elements in prostate cancer. TMPRSS2-ETV4 fusions occur less frequently than TMPRSS2-ERG fusions but are functionally analogous oncogenic events.

Alterations observed in the corpus

• TMPRSS2-ETV4 fusion identified in 2 prostate cancer PDX models (MDA PCa PDX series); both fusions correlated with increased ETV4 expression, confirming their functional activity PMID:38488813.
• Recurrent ETS fusion in mCRPC (part of 56% ETS-fusion prevalence) PMID:26000489
• Defines a less common ETS-fusion subtype (4%) in primary prostate cancer PMID:26544944

Cancer types (linked)

• PRAD — TMPRSS2-ETV4 fusion with confirmed ETV4 overexpression in 2/44 PDX models PMID:38488813.

Co-occurrence and mutual exclusivity

• Mutually exclusive with TMPRSS2-ERG fusion (by definition, as TMPRSS2 is fused to either ERG or ETV4) in the PDX cohort PMID:38488813.

Therapeutic relevance

• Not reported in the corpus.

Open questions

• Whether TMPRSS2-ETV4 fusion-positive tumors have distinct clinical behavior compared to TMPRSS2-ERG fusion-positive tumors is unresolved PMID:38488813.

Sources

• PMID:38488813

• PMID:26000489

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