FAAH2
Overview
FAAH2 (Fatty Acid Amide Hydrolase 2) encodes a lipid-metabolizing enzyme involved in endocannabinoid degradation. It was identified as a significantly mutated gene in chromophobe renal cell carcinoma (chRCC) through exome sequencing, though its functional role in cancer is uncharacterized.
Alterations observed in the corpus
- Significantly mutated in chromophobe RCC (chRCC) by whole-exome sequencing of 167 non-clear cell RCCs; lacks functional characterization in cancer PMID:25401301.
Cancer types (linked)
- CHRCC (chromophobe RCC): significantly mutated gene; driver versus passenger status is unestablished PMID:25401301.
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data reported in the corpus.
Therapeutic relevance
- No direct therapeutic associations reported in the corpus.
Open questions
- Oncogenic versus passenger role of FAAH2 in chRCC requires functional characterization PMID:25401301.
Sources
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