FAT3

Overview

FAT3 encodes a member of the FAT cadherin family, large transmembrane proteins involved in cell polarity, tissue growth control, and Hippo signaling. FAT3 was identified as a significantly mutated gene above background noise in high-grade serous ovarian carcinoma (HGSOC), suggesting a tumor suppressor role in ovarian cancer.

Alterations observed in the corpus

  • FAT3 was among the 9 genes significantly mutated above background in HGSOC (489 samples) by TCGA integrated genomic analysis, identified by whole-exome sequencing of 316 tumors PMID:21720365
  • Truncating mutations identified in adenoid cystic carcinoma (ACC); protocadherin with functional growth-suppressor knockdown phenotype PMID:23685749
  • Recurrent truncating mutations in ESCC; mutually exclusive with FAT1 and FAT2 (n=139 tumors by whole-exome/targeted sequencing) PMID:24686850

Cancer types (linked)

  • HGSOC: FAT3 somatic mutations identified as significantly recurrent above background mutation rate in a cohort of 489 stage II-IV tumors PMID:21720365

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic targeting established; potential relevance through Hippo pathway dysregulation.

Open questions

  • Functional role of FAT3 mutations in HGSOC and whether they are true drivers or passengers relative to the dominant TP53 mutation background remains unclear.

Sources

  • PMID:21720365 — TCGA integrated genomic analysis of ovarian carcinoma (HGSOC)

This page was processed by crosslinker on 2026-05-09. - PMID:23685749

This page was processed by crosslinker on 2026-05-09. - PMID:24686850

This page was processed by wiki-cli on 2026-05-11.