FER
Overview
FER encodes a cytoplasmic tyrosine kinase of the FPS/FES family involved in cell adhesion, migration, and growth factor receptor signaling. FER is implicated in multiple oncogenic contexts as a component of structural rearrangements and as a signaling mediator downstream of receptor tyrosine kinases.
Alterations observed in the corpus
- A possible TERT-FER inversion was identified in acral lentiginous melanoma patient 29, who also harbored a TERT-PDCD1LG2 interchromosomal rearrangement; the TERT-FER event was noted as a structural candidate requiring further validation PMID:28373299
Cancer types (linked)
- Acral lentiginous melanoma (ALM): FER identified as a candidate rearrangement partner of TERT via putative inversion in a single patient PMID:28373299
Co-occurrence and mutual exclusivity
- TERT-FER putative inversion co-occurred with a TERT-PDCD1LG2 interchromosomal rearrangement in the same tumor, suggesting complex structural rearrangements at the TERT locus PMID:28373299
Therapeutic relevance
- No direct therapeutic implications reported in the corpus for FER alterations at this time.
Open questions
- Whether the TERT-FER inversion produces an expressed fusion or represents a passenger structural event in ALM requires confirmation by RNA-seq or functional assays PMID:28373299
Sources
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