FEV
Overview
FEV (FEV Transcription Factor, ETS Family Member) encodes an ETS family transcription factor. In Ewing sarcoma, FEV is an ETS-family fusion partner of EWSR1, though its specific frequency in large cohorts is not well documented.
Alterations observed in the corpus
- Listed as an ETS-family fusion partner of EWSR1 in Ewing sarcoma alongside FLI1, ERG, and ETV1; specific case count in the 112-tumor WGS cohort not separately reported PMID:25223734.
Cancer types (linked)
- ES (Ewing sarcoma): ETS-family fusion partner of EWSR1 PMID:25223734.
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data specific to FEV reported in the corpus.
Therapeutic relevance
- No direct therapeutic associations reported in the corpus.
Open questions
- Frequency and clinical significance of EWSR1-FEV fusions in Ewing sarcoma relative to other ETS-family partners is not resolved in this cohort PMID:25223734.
Sources
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