FLG

Overview

FLG (Filaggrin) encodes a structural protein critical for skin barrier function. In cancer genomics, FLG has been identified as a MutSigCV-significant gene in pancreatic ductal adenocarcinoma. Its large size and hypermutable nature mean false-positive classification requires careful interpretation.

Alterations observed in the corpus

  • MutSigCV-significant gene in pancreatic ductal adenocarcinoma (PDAC); functional role in PDA biology remains to be validated PMID:25855536
  • Listed among additional recurrently altered candidate driver genes in medulloblastoma identified in the ICGC/MAGIC 491-tumor whole-genome sequencing cohort, stratified across subgroups PMID:28726821

Cancer types (linked)

  • PAAD: Identified among novel MutSigCV-significant genes not previously highlighted in PDAC; requires functional validation PMID:25855536

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic targeting reported in the corpus.

Open questions

  • FLG is a large gene; whether its mutations in PDAC represent true drivers or statistical artifacts of gene size requires functional validation.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:28726821

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