FLT1

Overview

FLT1 (FMS-like tyrosine kinase 1), also known as VEGFR1, is a receptor tyrosine kinase that binds VEGF-A, VEGF-B, and placental growth factor (PlGF). It plays a role in angiogenesis and vascular development. FLT1 amplification has been observed in rare neuroendocrine neoplasms and is implicated in tumor angiogenesis.

Alterations observed in the corpus

• Amplification identified in ovarian mixed adenoneuroendocrine carcinoma (MiNEN) case PN19 in a precision oncology cohort for neuroendocrine neoplasms PMID:24326773
• FLT1 (VEGFR1) mutations are among the low-frequency RTK hits identified in advanced thyroid cancers (PDTC/ATC) by MSK-IMPACT 341-gene sequencing (n=117 tumors) PMID:26878173

Cancer types (linked)

• Neuroendocrine neoplasms (MiNEN): focal amplification observed PMID:24326773

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24326773

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