FN1

Overview

FN1 (Fibronectin 1) encodes a large extracellular matrix glycoprotein that mediates cell adhesion, migration, and signaling through integrin receptors. In cancer, FN1 is a key marker of cancer-associated fibroblast (CAF) activation and epithelial-to-mesenchymal transition (EMT), and its upregulation in the tumor stroma is associated with poor prognosis in multiple cancer types.

Alterations observed in the corpus

• Upregulated as a CAF activation marker in gastric fibroblasts under high-stiffness conditions (16 kPa), downstream of YAP/TAZ mechanotransduction; used as readout of CAF activation alongside ACTA2, CCN2, COL1A1, and COL4A1 in GBC stroma PMID:24997986

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24997986

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