FOXM1
Overview
FOXM1 (Forkhead Box M1) is a proliferation-associated transcription factor that activates genes involved in cell cycle progression, DNA repair, and metastasis. FOXM1 is broadly upregulated in aggressive cancers and is considered a master regulator of the proliferative phenotype. In meningioma, FOXM1 marks the most proliferative and aggressive molecular group.
Alterations observed in the corpus
- FOXM1 is a key proliferation-associated transcription factor whose transcriptional network is enriched in MG4 (the most proliferative/aggressive integrative molecular group) meningiomas; co-enriched with MYC in this group PMID:34433969.
- FOXM1 was identified as a recurrently amplified and overexpressed gene in HGSOC, driving cell cycle progression in ovarian carcinoma PMID:21720365
- Upregulated in the basal-like IntClust 10 subgroup (METABRIC, 2,000 tumors) as part of a chromosome 5q deletion-associated trans-acting mitotic network PMID:22522925
- FOXM1 identified as a low-frequency (1-1.4%) mitotic-checkpoint and cell-cycle hit in rhabdomyosarcoma (RMS) comprehensive genomic characterization PMID:24436047
Cancer types (linked)
- MNG — transcriptional network enriched in MG4, the most aggressive meningioma molecular group PMID:34433969.
Co-occurrence and mutual exclusivity
- Co-enriched with MYC in the MG4 meningioma proliferative transcriptional program PMID:34433969.
Therapeutic relevance
- Vorinostat (HDAC inhibitor) showed selective efficacy against MG4 meningiomas in vitro and in vivo; FOXM1 enrichment in MG4 may be relevant for stratifying response to this agent PMID:34433969.
Open questions
- Whether FOXM1 is a viable direct therapeutic target (vs. a transcriptional biomarker) in meningioma is unresolved PMID:34433969.
Sources
This page was processed by crosslinker on 2026-05-09. - PMID:21720365
This page was processed by crosslinker on 2026-05-09. - PMID:22522925
This page was processed by crosslinker on 2026-05-09. - PMID:24436047
This page was processed by crosslinker on 2026-05-09.