FOXP2

Overview

FOXP2 encodes a forkhead box transcription factor best known for its role in speech and language development. Somatic mutations in FOXP2 have been identified in adenoid cystic carcinoma (ACC) as part of comprehensive genomic profiling.

Alterations observed in the corpus

• Mutation identified in ~3% of adenoid cystic carcinoma (ACC) cases; functional significance in ACC pathogenesis not yet established PMID:23685749
• FOXP2 identified as a recurrently SV-affected gene (structural variant) in rhabdomyosarcoma (RMS), associated with tyrosine kinase signaling and muscle development pathways PMID:24436047

Cancer types (linked)

• ACC (adenoid cystic carcinoma) — somatic mutations at ~3% frequency PMID:23685749

Co-occurrence and mutual exclusivity

• Mutated in the context of a diverse ACC mutational landscape that includes MYB/NFIB alterations, chromatin-remodeling gene mutations, and PI3K pathway alterations PMID:23685749

Therapeutic relevance

• No direct therapeutic implication reported for FOXP2 in ACC PMID:23685749

Open questions

• Functional role of FOXP2 mutations in ACC is unknown; whether they are driver events or passenger mutations has not been determined PMID:23685749

Sources

• PMID:23685749

This page was processed by crosslinker on 2026-05-09. - PMID:24436047

This page was processed by crosslinker on 2026-05-09.