FUS

Overview

FUS (FUS RNA Binding Protein) encodes a TET-family RNA-binding protein. In Ewing sarcoma, FUS is an alternative TET-family N-terminal fusion partner in rare cases where EWSR1 is not the fusion driver.

Alterations observed in the corpus

• Listed as an alternative TET-family N-terminal fusion partner in rare Ewing sarcoma cases; mechanistically related to EWSR1 as both are TET-family RNA-binding proteins PMID:25223734.
• FUS fusions (e.g., FUS-ERG, FUS-FEV) were identified as alternative oncogenic drivers in a subset of Ewing sarcoma cases PMID:28199314

Cancer types (linked)

• ES (Ewing sarcoma): rare alternative TET-family N-terminal fusion partner (alongside TAF15) in Ewing sarcoma cases lacking EWSR1 fusions PMID:25223734.

Co-occurrence and mutual exclusivity

• No co-occurrence or mutual exclusivity data specific to FUS reported in the corpus.

Therapeutic relevance

• No direct therapeutic associations reported in the corpus.

Open questions

• Frequency and clinical significance of FUS-ETS fusions in Ewing sarcoma relative to EWSR1-ETS fusions is not resolved in this cohort PMID:25223734.

Sources

• PMID:25223734

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