G6PD

Overview

G6PD encodes glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the pentose phosphate pathway (PPP). The PPP generates NADPH for antioxidant defense and ribose-5-phosphate for nucleotide biosynthesis, making G6PD central to the metabolic reprogramming observed in many cancers. In ccRCC, G6PD is highlighted as part of the Warburg-like metabolic shift in aggressive tumors.

Alterations observed in the corpus

  • Highlighted as a downstream pathway and SCNA feature in focal-deletion analyses in clear-cell renal cell carcinoma (ccRCC); pentose phosphate pathway activity (including G6PD) proposed as a candidate therapeutic-vulnerability indicator given the Warburg-like metabolic shift in aggressive tumors PMID:23792563

Cancer types (linked)

  • CCRCC — G6PD-mediated pentose phosphate pathway activity is part of the metabolic reprogramming landscape identified by comprehensive multi-omic profiling; proposed as both prognostic and therapeutic target PMID:23792563

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Pentose phosphate pathway including G6PD proposed as a candidate therapeutic-vulnerability indicator in aggressive ccRCC alongside AMPK and ACC PMID:23792563

Open questions

  • Specific frequency of G6PD copy-number or expression alterations is not individually detailed in the ccRCC TCGA cohort PMID:23792563

Sources

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