GFI1B
Overview
GFI1B (Growth Factor Independent 1B Transcriptional Repressor) encodes a zinc-finger transcriptional repressor closely related to GFI1, with roles in hematopoiesis and megakaryocyte development. In medulloblastoma, GFI1B is aberrantly induced by structural variant-driven enhancer-hijacking, making it a top CESAM-confirmed enhancer-hijacking target in Group 3 and Group 4 tumors, mutually exclusive with GFI1 activation.
Alterations observed in the corpus
- SV-driven aberrant induction (enhancer-hijacking) in Group 3 and Group 4 medulloblastoma; GFI1B was the top CESAM-confirmed enhancer-hijacking target in this analysis; mutually exclusive with GFI1 activation; identified in the ICGC/MAGIC 491-tumor WGS cohort spanning 1,256 methylation-profiled cases PMID:28726821.
Cancer types (linked)
- MBL: Top CESAM-confirmed enhancer-hijacking target; SV-driven induction distributed across Group 3 and Group 4 medulloblastoma subtypes, mutually exclusive with GFI1 activation PMID:28726821.
Co-occurrence and mutual exclusivity
- Mutually exclusive with GFI1 SV-driven induction in medulloblastoma Group 3 and Group 4 PMID:28726821.
Therapeutic relevance
- No direct therapeutic targets reported in the corpus to date.
Open questions
- Functional distinction between GFI1B and GFI1 enhancer-hijacking events in medulloblastoma and their downstream transcriptional consequences remain to be defined.
Sources
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