GPR149

Overview

GPR149 (G Protein-Coupled Receptor 149) is an orphan G protein-coupled receptor. It was identified as a significantly mutated gene in African American colorectal cancers, forming part of the ethnicity-enriched mutational panel in CRC.

Alterations observed in the corpus

• Identified as a significantly mutated gene in the 20-gene AA-enriched CRC panel (significantly mutated in both discovery and validation cohorts) PMID:25583493

Cancer types (linked)

• Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

• Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

• PMID:25583493

This page was processed by entity-page-writer on 2026-05-14.