GSK3B

Overview

One-paragraph summary of the gene’s role and why it matters in cancer genomics.

Alterations observed in the corpus

  • Mutation classes (missense / truncating / fusion / amplification / deletion) with links to the papers that report them.
  • Identified among significantly mutated genes in 188 primary LUAD tumours (TSP cohort); Wnt pathway kinase that phosphorylates beta-catenin for degradation. PMID:18948947
  • Degraded by HBx-mediated ubiquitination in HBV-related HCC, leading to dysregulated CTNNB1 stability and activation of the Wnt/beta-catenin pathway PMID:22634756
  • Recurrent disruptive rearrangement by chromoplexy affecting a gene implicated in prostate cancer signaling PMID:23622249
  • Elevated GSK3 protein (by RPPA) detected in MAML3 fusion-positive pheochromocytoma/paraganglioma (PHC/PGNG) as part of the Wnt-pathway activation signature in the Wnt-altered subtype; elevated alongside β-catenin and DVL3 (TCGA PCPG study, n=173) PMID:28162975.

Cancer types (linked)

  • Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

  • Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

  • Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

  • Conflicts or unresolved findings across papers.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:18948947

This page was processed by crosslinker on 2026-05-09. - PMID:22634756

This page was processed by crosslinker on 2026-05-09. - PMID:23622249

This page was processed by crosslinker on 2026-05-09. - PMID:28162975

This page was processed by wiki-cli on 2026-05-14.