H1-4

Overview

H1-4 (formerly HIST1H1E) is a linker histone gene encoding histone H1.4, which regulates higher-order chromatin compaction and transcriptional silencing. It was identified as a novel driver candidate in CLL, where mutations appear to arise early (clonal) and may alter chromatin accessibility across the tumor genome.

Alterations observed in the corpus

  • Novel CLL driver candidate identified by WES of 160 tumors (Broad cohort); mutations were clonal in 5/5 affected samples, indicating an early origin in CLL evolution PMID:23415222
  • Recurrently altered driver-gene cluster member in DLBCL, grouped within signaling, cell growth, B-cell development, and transcription/translation functional categories across 1001 uniformly-treated patients. PMID:28985567

Cancer types (linked)

  • CLL: Novel driver candidate; clonal mutations in 5/5 affected samples suggest early clonal sweep; mechanistically linked to altered chromatin compaction PMID:23415222

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No targeted therapies currently linked to H1-4 in this corpus. Chromatin compaction role may interact with BET bromodomain or EZH2 inhibitor strategies.

Open questions

  • Validation of H1-4 as a bona fide CLL driver in independent cohorts is explicitly noted as outstanding PMID:23415222

Sources

This page was processed by entity-page-writer on 2026-05-06. - PMID:28985567

This page was processed by entity-page-writer on 2026-05-15.