H1-5

Overview

H1-5 (H1.5 Linker Histone, Cluster Member) is a linker histone involved in chromatin compaction and gene regulation. Formerly designated HIST1H1B under an older HUGO nomenclature, the gene was renamed H1-5 in a 2021 HGNC update. It has been identified as a chromatin modification driver in chronic lymphocytic leukemia (CLL).

Alterations observed in the corpus

  • Identified as a chromatin modification driver in CLL (HUGO symbol updated from HIST1H1B to H1-5); enriched in a comprehensive WES study of 538 CLL patients PMID:26466571

Cancer types (linked)

  • CLL — novel driver candidate in chronic lymphocytic leukemia, classified among chromatin modification drivers alongside ASXL1, BAZ2B, and IKZF3 PMID:26466571

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

  • Functional validation of H1-5 as a CLL driver beyond statistical discovery (MutSig2CV) is pending PMID:26466571

Sources

This page was processed by crosslinker on 2026-05-14.