HECTD4
Overview
HECTD4 (HECT Domain E3 Ubiquitin Protein Ligase 4) encodes a HECT-family E3 ubiquitin ligase involved in protein ubiquitination and turnover. Its role in cancer genomics is emerging; it has been identified as a rearrangement partner in acral lentiginous melanoma (ALM), a rare UV-independent melanoma subtype with limited targeted treatment options.
Alterations observed in the corpus
- Identified as a rearrangement partner gene in an integrated genomic study of acral lentiginous melanoma (34 patients; whole-genome and whole-exome sequencing); specific alteration type and frequency not detailed in the paper’s primary findings table PMID:28373299
Cancer types (linked)
- ACRM (Acral Lentiginous Melanoma): Identified as a structural variant partner gene in ALM, a UV-independent melanoma subtype characterized by frequent somatic TERT aberrations, PAK1 copy gains, and BRAF/NRAS/NF1 driver mutations PMID:28373299
Co-occurrence and mutual exclusivity
- Rearrangement observed in the context of TERT-dominated genomic landscape in ALM; specific co-mutation or exclusivity data not reported PMID:28373299
Therapeutic relevance
- No direct therapeutic targeting of HECTD4 reported in this corpus.
Open questions
- Functional impact of HECTD4 rearrangements in ALM is unknown; whether HECTD4 is a passenger or contributes to oncogenic signaling is unresolved PMID:28373299
Sources
This page was processed by crosslinker on 2026-05-14.