HERC1

Overview

HERC1 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 1) is a large E3 ubiquitin ligase. A HERC1 missense mutation (P3278S) was identified as the source of an immunogenic neoantigen that drove a validated CD8+ T cell response in a pembrolizumab exceptional responder with NSCLC, establishing HERC1 as a neoantigen-generating locus of clinical significance.

Alterations observed in the corpus

  • P3278S missense mutation generated the validated HLA-A-restricted neoantigen ASNASSAAK that drove a measurable, treatment-induced CD8+ T cell response in an exceptional responder to pembrolizumab in NSCLC PMID:25765070

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

  • HERC1 P3278S-derived neoantigen ASNASSAAK was validated as HLA-A-restricted and drove CD8+ T cell response in a patient achieving durable clinical benefit on pembrolizumab PMID:25765070

Open questions

  • Conflicts or unresolved findings across papers.

Sources

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