HOXD8
Overview
HOXD8 is a homeobox transcription factor belonging to the HOXD cluster on chromosome 2q31. HOX genes encode transcription factors that regulate developmental patterning; their dysregulation has been implicated in various cancers. HOXD8 has been identified as a candidate transcriptional-effector resistance gene in BRAF-inhibitor-treated melanoma.
Alterations observed in the corpus
- Nonsense mutation identified in one early-resistance tumor from a BRAF-inhibitor melanoma cohort; proposed as a candidate transcriptional-effector resistance gene for dabrafenib resistance PMID:24265153
Cancer types (linked)
- Melanoma: nonsense mutation in early BRAF-inhibitor resistance setting PMID:24265153
Co-occurrence and mutual exclusivity
Therapeutic relevance
- Loss-of-function mutation associated with early resistance to dabrafenib (BRAF inhibitor) in melanoma; proposed as contributing to pan-MAPK pathway resistance PMID:24265153
Open questions
- Whether HOXD8 loss mechanistically drives BRAF-inhibitor resistance or is a passenger event remains unresolved PMID:24265153
Sources
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