HSPA1A

Overview

HSPA1A (Heat Shock Protein Family A Member 1A; commonly HSP70) is an inducible molecular chaperone that facilitates protein folding and stress response. In hepatocellular carcinoma (HCC), HSPA1A protein expression is one of the three markers in the EASL-endorsed diagnostic IHC triplet for early HCC, reflecting stress-response upregulation in malignant hepatocytes.

Alterations observed in the corpus

HSPA1A (HSP70) protein expression is a component of the EASL-endorsed diagnostic IHC triplet (alongside GLUL/glutamine synthetase and GPC3) for early HCC diagnosis PMID:24735922

Cancer types (linked)

HCC — diagnostic IHC marker in the EASL-endorsed triplet panel for early HCC PMID:24735922

Co-occurrence and mutual exclusivity

Co-expressed with GLUL and GPC3 as part of the EASL-endorsed IHC diagnostic triplet PMID:24735922

Therapeutic relevance

Open questions

Sources

PMID:24735922

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