HSPA5

Overview

HSPA5 (Heat Shock Protein Family A Member 5), also known as GRP78 or BiP, is an endoplasmic reticulum chaperone and a key component of the MHC class I antigen-processing machinery (APM). Somatic mutations in APM components including HSPA5 are enriched in tumor-infiltrating lymphocyte (TIL)-rich tumors, suggesting immune-escape selection pressure. HSPA5 also plays roles in unfolded protein response and cancer cell survival.

Alterations observed in the corpus

  • Component of the MHC class I antigen-processing machinery (APM); collectively enriched for somatic mutations in TIL-rich colorectal cancer tumors in a 619-sample neoantigen study, consistent with immune-escape selection (alongside B2M, CALR, CANX, PDIA3, TAP1, TAP2, TAPBP) PMID:27149842

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

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